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Literature summary extracted from

  • Zavacki, A.M.; Arrojo E Drigo, R.; Freitas, B.C.; Chung, M.; Harney, J.W.; Egri, P.; Wittmann, G.; Fekete, C.; Gereben, B.; Bianco, A.C.
    The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase (2009), Mol. Cell. Biol., 29, 5339-5347.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.99.4 into a D10 vector Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.99.4 endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.4 L-thyroxine + AH2 Homo sapiens
-
 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 L-thyroxine + AH2
-
 Homo sapiens 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.21.99.4 dimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 type 2 iodothyronine deiodinase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.21.99.4 Homo sapiens substrate-dependent down-regulation, WSB-1-mediated ubiquitination inactivates the enzyme and targets it for proteasomal degradation, TEB4 interacts with the enzyme and mediates loss of activity and protein down
1.21.99.4 Homo sapiens ubiquitinated enzyme can be reactivated and rescued from proteosomal degradation by the von Hippel-Lindau protein-interacting deubiquitinating enzyme-1, TEB4 knockdown increases activity and protein level of iodothyronine deiodinase 2 up